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Kansai-based Clinic Combining Cancer Immunotherapy,
Hyperthermia & Reductive Electron Therapy

Reservations & Inquiries by PhoneTEL.072-640-0170
Outside of clinic hours, an answering machine will respond.

3F Goda C&E Building, 2-13-14 Kamikorori, Ibaraki City, Osaka 567-0065

Cancer Immunotherapyimmunotherpy

Cancer Immunotherapy

Tumor-Infiltrating Lymphocyte Therapy(TIL Therapy)


　While pleural and ascitic fluid are typically drained and discarded, Tumor-Infiltrating Lymphocyte Therapy (TIL Therapy) is a method that makes use of the cells contained within them.
　In TIL Therapy, antigen-recognizing T cells play the central role. Pleural and ascitic fluid contain cells such as Cytotoxic T Cells and Helper T Cells that act to attack cancer cells, while regulatory T cells — which suppress attacks on cancer cells — are barely present.
　By culturing, activating, and expanding the T cells contained in pleural and ascitic fluid, their ability to attack cancer can be enhanced.

Treatment Flow
　Pleural and abdominal punctures are performed, and lymphocytes and cancer cells are separated using a special method. Anti-CD3 antibody, IL-2, and other reagents are added, and the cells are cultured for approximately 2 to 3 weeks. The culture medium is then removed and the cells washed; the activated and expanded lymphocytes are suspended in saline and returned to the body.



From the day of puncture or blood draw to infusion, the first session takes approximately 3 weeks. Subsequent infusions take about 2 weeks. Because the number of sessions is limited, treatment typically averages 4 to 6 infusions.

Treatment Duration & Frequency　　　　　　
 Duration  3 to 6 months
 Frequency The number of sessions is determined through consultation with the physician.


Risks & Side Effects
　As immune cell therapy uses the patient's own immune cells, mild fever or rash may occur in some cases, but no other side effects are observed, and there is minimal burden on the body.
　Because side effects are extremely rare, treatment can be continued while maintaining quality of life.

Treatment Outcomes at Our Clinic
　We have non-surgical pancreatic cancer patients who, after being given 1–2 months to live at other hospitals, have maintained good QOL and lived ordinary daily lives for more than 2 years. We have also seen many cases in which the pleural fluid of lung cancer patients disappeared within several months after TIL treatment.